Central University of Gujarat, India
Title: Polymeric carriers for drug delivery system: Comparison study of effects of Methotrexate to chitosan derivative and 1st tier dendrimer on its Binding, release and Breast cancerous cells for Toxicological estimation
Reena Tondwal has completed her MSc from Banasthali University and MPhil from Central University of Gujarat. Now she is a research scholar and pursuing her PhD from Central University of Gujarat, India. She has published 2 papers and 3rd paper communicated in reputed journals. She has her expertise in Polymer and Dendrimer Chemistry and Drug Delivery.
A comparative study of chitosan derivative with methionine (CM) and trimesoyl 1, 3, 5-tridipropyl malonate ester (TTDPM) as drug delivery vehicle encapsulated with the model drug ( Methotrexate: MTX) individually, for breast cancer drug delivery system. MTX-TTDPM and MTX-CM were prepared using a 1 : 1 ratio of MTX, TTDPM and MTX, CM in acetone and 0.4 % acetic acid + acetone medium respectively at RT followed by 24 h. MTX interact with TTDPM and CM by hydrogen bonding confirmed through FTIR and further characterized by SEM and DLS for their morphological and narrow particle size distribution respectively. TTDPM and CM has functionality which assistances to bind MTX anticancer drugs for their imminent use in breast cancer drug delivery system. Effects of TTDPM, CM and their complexes with MTX were tested on cell viability by SRB assay using a human breast cancer cell line (MCF-7), remarkably inhibits the growth of MCF-7 breast cancer cells.